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About

慈濟大學醫學生物技術碩士班
花蓮市中央路三段701號
03-8565301-2321
網站管理者:HSU

Lo

羅時燕教授(所長)

分機:2323 / 2322 (Lab/Office)
所長分機:2320 
Email:
losylo@mail.tcu.edu.tw

 


 

  Research background

  • Expression and characterization of hepatitis B virus polymerase gene in E. coli.
  • Molecular and cellular biology of hepatitis C virus.
Special techniques

      General molecular biology techniques

Research Interests

  • Study on the replication and pathogenesis of hepatitis C virus
  • Study on the replication and pathogenesis of influenza A virus
  • Molecular mechanism(s) of RNA interference

Publication

  • Wang, Li-Yu, Hans Hsienhong Lin, Tsung-Dao Lee,, Ya-Fang Wu, Chi-Tan Hu, Mu-Liang Cheng, and Shih-Yen Lo. (2005) Human Leukocyte Antigen Phenotypes and Hepatitis C Viral Load. Journal of Clinical Virology 32: 144-150.
  • Lee, Yi-Nung, Li-Kuang Chen, Hsin-Chieh Ma, Hui-Hua Yang , Hsin-Pai Li, and Shih-Yen Lo (2005) Thermal aggregation of SARS-CoV membrane protein. Journal of Virologic Methods 129: 152-161.
  • Hsin-Chieh Ma, Yi-Yung Ku, Yi-Ching Hsieh, Shih-Yen Lo (2007) Characterization of the cleavage of signal peptide at the C-terminus of hepatitis C virus core protein by signal peptide peptidase. Journal of Biomedical Sciences 2007 Jan;14(1):31-41. 
  • Hsin-Chieh Ma, Chiu-Ping Fang, Yi-Ching Hsieh, Shih-Chi Chen, Hui-Chun Li, Shih-Yen Lo (2008) Expression and membrane integration of SARS-CoV M protein. Journal of Biomedical Sciences 15(3):301-10. 
  • Hsin-Chieh Ma, Ta-Wei Lin , Huichun Li, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga, Yu-Li Chuang, Jing-Hsiung Ou, Shih-Yen Lo (2008) Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc. Journal of Biomedical Sciences 15(4):417-25. 
  • Yi-Ching Hsieh, Hui-Chun Li, Shih-Chi Chen, Shih-Yen Lo (2008) Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus. Journal of Biomedical Sciences 15(6):707-17. 
  • Shih-Chi Chen, Shih-Yen Lo, Hsin-Chieh Ma, Hui-Chun Li (2009) Expression and membrane integration of SARS-CoV E protein and its interaction with M protein. Virus Gene 38:365-371. (SCI)
  • Chia-Wei Chang, Hui-Chun Li, Che-Fang Hsu, Chiao-Yen Chang, Shih-Yen Lo. (2009) Increased ATP generation in the host cell is required for efficient vaccinia virus production. Journal of Biomedical Science 16:80. (SCI)
  • Chee-Hing Yang, Hui-Chun Li, Jeng-Geng Jiang, Che-Fang Hsu, Yi-Jen Wang, Meng-Jiun Lai, Yue-Li Juang, Shih-Yen Lo. Enterovirus type 71 2A protease functions as a transcriptional activator in yeast. Journal of Biomedical Science 2010, 17:65.(SCI)
  • Shih-Ching Chan, Shih-Yen Lo , Je-Wen Liou , Min-Ching Lin , Ciao-Ling Syu , Meng-Jiun Lai ,Yi- Cheng Chen, Hui-Chun Li. Visualization of the structures of the hepatitis C virus replication complex. Biochemical and Biophysical Research Communications 404 (2011) 574–578.