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About

慈濟大學醫學生物技術碩士班
花蓮市中央路三段701號
03-8565301-2321
網站管理者:HSU

吳文陞副教授

分機:2327 / 2328 (Lab/Office)
 
Email:
wuws@mail.tcu.edu.tw

 


 英文網頁介紹(English Resume) 

 Research background 
  分子生物       臨床生化      生物化學     分析化學

實驗室發展方向
  1.細胞生長調控之分子機轉
  2.癌症研究
  3.抗癌的基因療法
  4.遺傳疾病之分子診斷
Publications
  • Wen-Sheng Wu(第三作者)& Wen-Chuan Wu et. al.(2000) Concentration of vascular endothelial growth factor in the subretinal fluid of retinal detachment.J. of Ocular Phamacology and Theraputics.(SCI).
  • Jin L. Tsai, Wen-S Wu, Hei-H Lee (2000) Qualitative determination of urinary morphine by capillary zone electrophoresis and ion trap spectrometry. Electrophoresis 21: 1580-1596. (SCI, IP 3.447)
  • Wen-Sheng Wu and Hsue-Yin Heu (2001) Involvement of p15INK4b and p-16 INK4a gene expression in Saikosaponin a and TPA induced growth inhibition of HepG2 cells. Biochem. Biophys. Res.Commun. 285, 183-187
  • Wen-Sheng Wu (2003) ERK signalling pathway is involved in p15INK4b and p-16 INK4a gene expression HepG2 growth inhibition triggered by Saikosaponin a and TPA and Saikosaponin a. Oncogene 22(7):955-963. 
  • Wen-Sheng Wu & Jun-Ming Huang (2005) Activation of protein kinase C alpha is required for TPA-triggered ERK(MAPK) signaling and growth inhibition of human hepatoma cell HepG2. Journal of Biomedical Science 12:289-296.
  • Chi-Tan Hu, Jia-Ru Wu, Tsu Yao Chang, Chuan-Chu Cheng, Wen-Sheng Wu. The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2. J Biomed Sci (2008) 15:343–355
  • Wen-Sheng Wu , Jia-Ru Wu, Chi-Tan Hu. Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species. Cancer Metastasis Rev (2008) 27:303–314.
  • Rong Kung Tsai , Chung Hsing Chang , Chi Ming Hseu , Shen Ming Chang, Jia-Ru Wu , Hwei-Zu Wang , Wen Chen Wu , Wen Sheng Wu *. Ethambutol induces PKC-dependent cytotoxic and antiproliferative effects on human retinal pigment cells. Experimental Eye Research 87 (2008) 594–603.
  • Chi-Tan Hu, Tsu-Yao Chang, Chuan-Chu Cheng, Chun-Shan Liu, Jia-Ru Wu, Ming-Che Li and Wen-Sheng Wu. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b . FEBS Journal 277 (2010) 1202–1218.
  • Rong Kung Tsai, Ming Shan He, Zih-Yao Chen, Wen Chen Wu, Wen Sheng Wu. PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. Molecular Vision 2011; 17:1564-1576.
  • Chi-Tan Hu, Jia-Ru Wu, Chuan-Chu Cheng, Sindy Wang, Hsiao-Ting Wang, Ming-Che Lee, Ling-Jung Wang, Siou-Mei Pan, Tsu-Yao Chang, Wen-Sheng Wu. Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. Clin Exp Metastasis (2011) 28:851–863 .
  • Chen YJ, Tsai RK, Wu WC, He MS, Kao YH, Wu WS*  . Enhanced PKCδ and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF.  PLoS One. 2012;7(9):e44937.
  • Hu CT, Cheng CC, Pan SM, Wu JR, Wu WS*. PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2. Cell Signal. 2013;25(6):1457-67.
  • Hu CT, Wu JR, Wu WS*. The role of endosomal signaling triggered by metastatic growth factors in tumor progression. Cell Signal. 2013 l;25(7):1539-45.