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About

慈濟大學醫學生物技術碩士班
花蓮市中央路三段701號
03-8565301-2321
網站管理者:HSU

蘇伯琦副教授

Email:pcsoo@mail.tcu.edu.tw

分機: 2333/ 2347 (Lab/Office)

Research background:

 .Clinical microbiology
.Molecular microbiology
.Applied microbiology

Special techniques:
.General molecular biology techniques

.Molecular diagnosis of microorganisms
 
Research Interests:
.Bacterial two-component system regulated prodigiosin synthesis
.Development of 1,3-propanediol high production strain
.PHA project
.Development of TB diagnosis kit

Publication
  • Horng, Y.T., Deng, S.C., Daykin, M., Soo, P.C., Wei, J.R., Luh, K.T., Ho, S.W., Swift, S., Lai, H.C. and Williams, P. (2002) The LuxR family protein SpnR functions as a negative regulator of N-acylhomoserine lactone-dependent quorum sensing in Serratia marcescens. Molecular microbiology 45, 1655-1671.
  • Wei, J.R., Tsai, Y.H., Soo, P.C., Horng, Y.T., Hsieh, S.C., Ho, S.W. and  Lai, H.C. (2005) Biochemical characterization of RssA-RssB, a two-component signal transduction system regulating swarming behavior in Serratia marcescens. Journal of bacteriology 187, 5683-5690
  • Lai, H.C., Soo, P.C., Wei, J.R., Yi, W.C., Liaw, S.J., Horng, Y.T., Lin, S.M., Ho, S.W., Swift, S. and Williams, P. (2005) The RssAB two-component signal transduction system in Serratia marcescens regulates swarming motility and cell envelope architecture in response to exogenous saturated fatty acids. Journal of bacteriology 187, 3407-3414.
  • Soo, P.C., Wei, J.R., Horng, Y.T., Hsieh, S.C., Ho, S.W. and Lai, H.C. (2005) Characterization of the dapA-nlpB genetic locus involved in regulation of swarming motility, cell envelope architecture, hemolysin production, and cell attachment ability in Serratia marcescens. Infection and immunity 73, 6075-6084.
  • Wei, J.R., Tsai, Y.H., Horng, Y.T., Soo, P.C., Hsieh, S.C., Hsueh, P.R., Horng, J.T., Williams, P. and Lai, H.C. (2006) A mobile quorum-sensing system in Serratia marcescens. Journal of bacteriology 188, 1518-1525. 
  • Wei, J.R., Soo, P.C., Horng, Y.T., Hsieh, S.C., Tsai, Y.H., Swift, S., Withers, H., Williams, P. and Lai, H.C. (2006) Regulatory roles of spnT, a novel gene located within transposon TnTIR. Biochemical and biophysical research communications 348, 1038-1046.
  • Horng, Y.T., Soo, P.C., Shen, B.J., Hung, Y.L., Lo, K.Y., Su, H.P., Wei, J.R., Hsieh, S.C., Hsueh, P.R. and Lai, H.C. (2006) Development of an improved PCR-ICT hybrid assay for direct detection of Legionellae and Legionella pneumophila from cooling tower water specimens. Water research 40, 2221-2229.
  • Soo, P.C., Horng, Y.T., Hsueh, P.R., Shen, B.J., Wang, J.Y., Tu, H.H., Wei, J.R., Hsieh, S.C., Huang, C.C. and Lai, H.C. (2006) Direct and simultaneous identification of Mycobacterium tuberculosis complex (MTBC) and Mycobacterium tuberculosis (MTB) by rapid multiplex nested PCR-ICT assay. Journal of microbiological methods 66, 440-448. 
  • Soo, P.C., Horng, Y.T., Lai, M.J., Wei, J.R., Hsieh, S.C., Chang, Y.L., Tsai, Y.H. and Lai, H.C. (2007) Pirin regulates pyruvate catabolism by interacting with the pyruvate dehydrogenase E1 subunit and modulating pyruvate dehydrogenase activity. Journal of bacteriology 189, 109-118
  • Soo, P.C., Horng, Y.T., Wei, J.R., Shu, J.C., Lu, C.C. and Lai, H.C. (2008) Regulation of swarming motility and flhDC(Sm) expression by RssAB signaling in Serratia marcescens. Journal of bacteriology 190, 2496-2504.
  • Soo, P.C., Horng, Y.T., Fu, Y.H., Lu, C.C. and Lai, H.C. (2008) A potential acyltransferase regulates swarming in Serratia marcescens. Biochemical and biophysical research communications 371, 462-467.
  •  Soo, P.C., Horng, Y.T., Chang, K.C., Wang, J.Y., Hsueh, P.R., Chuang, C.Y., Lu, C.C. and Lai, H.C. (2009) A simple gold nanoparticle probes assay for identification of Mycobacterium tuberculosis and Mycobacterium tuberculosis complex from clinical specimens. Molecular and cellular probes 23, 240-246.
  • Chih-Ching Chien, Chian-Chiao Hong, Po-Chi Soo, Yu-Hong Wei , Shan-Yu Chen, Mei-Ling Cheng, Yi-Ming Sun. (2010)Functional Expression of phaCAB Genes from Cupriavidus taiwanensis Strain 184 in Escherichia coli for Polyhydroxybutyrate Production. Appl Biochem Biotechnol 162:2355~2364.(SCI) 
  •  Horng YT, Chang KC, Chien CC, Wei YH, Sun YM, Soo PC*. Enhanced polyhydroxybutyrate (PHB) production via the coexpressed phaCAB and vgb genes controlled by arabinose P promoter in Escherichia coli. Lett Appl Microbiol. 2010 Feb;50(2):158-67. (SCI)
  • Horng YT, Chang KC, Chou TC, Yu CJ, Chien CC, Wei YH, Soo PC. Inactivation of dhaD and dhaK abolishes by-product accumulation during 1,3-propanediol production in Klebsiella pneumoniae. Journal of Industrial Microbiology and Biotechnol. 2010 Apr. (37) 707-716. (SCI)
  • Yu-Tze Horng, Kai-Chih Chang, Yen-Ni Liu, Hsin-Chih Lai, Po-Chi Soo . The RssB/RssA two-component system regulates biosynthesis of the tripyrrole antibiotic, prodigiosin, in Serratia marcescens. International Journal of Medical Microbiology Volume 300, Issue 5, June 2010, Pages 304-312.(SCI)
  • Y.-T. Horng, C.-C. Chien, Y.-H. Wei, S.-Y. Chen, J.C.-W. Lan, Y.-M. Sun and P.-C. Soo. (2011) Functional cis-expression of phaCAB genes for poly (3-hydroxybutyrate) production by Escherichia coli. Letters in Applied Microbiology 52, 475–483. (SCI)
  • Meng-Jiun Lai, Nien-Tsung Lin, Anren Hu, Po-Chi Soo, Li-Kuang Chen, Long-Hui Chen, Kai-Chih Chang. Antibacterial activity of Acinetobacter baumannii phage 6AB2 endolysin (LysAB2) against both Gram-positive and Gram-negative bacteria. Appl Microbiol Biotechnol (2011) 90:529–539.(SCI)
  • Chih-Ching Chien, Hsiu-Hsiung Li, Po-Chi Soo, Shan-Yu Chen, Yu-Hong Wei, Wen-Ming Chen. Effects of Different Substrate Composition on Biosynthesis of Polyhydroxybutyrate-co-hydroxyvalerate by Recombinant Escherichia coli. Appl Biochem Biotechnol (2012) 166:796–804.(SCI)